Metabolism of Histone Deacetylase Proteins Opsonizes Tumor Cells to Checkpoint Inhibitory Immunotherapies.

摘要: LC3-associated phagocytosis, a distinct form of autophagy, plays key role in antigen presentation. Autophagy itself central the regulation cellular metabolism. Proteins that regulate autophagy include AMPK which senses high levels AMP, and mTOR, integrates amino acid fatty metabolism with autophagy. More recently, has been demonstrated to tumor cell immunogenicity via degradation histone deacetylase proteins. Individual drugs drug combinations activate ATM-AMPK pathway inactivate cause autophagosome formation. The maturation autophagosomes into autolysosomes causes autophagic proteins who transcription PD-L1, Class I MHCA, ODC IDO1. Indeed, do not contain an HDAC inhibitor can nevertheless act as de facto inhibitors, Such simultaneously kill cells immunogenic parallel opsonize checkpoint immunotherapies reduced expression IDO1, increased MHCA.