Harnessing preclinical mouse models to inform human clinical cancer trials.
作者： David H Gutmann , Kim Hunter-Schaedle , Kevin M Shannon
DOI: 10.1172/JCI28271
关键词:
摘要: The urgent need for better cancer treatments has stimulated interest in employing small-animal models to evaluate potential drug therapies. Robust mouse of many human cancers have been generated using sophisticated technologies engineering germ-line mutations. As we enter into an age targeted therapeutics, these strains provide novel platforms validating new anticancer drugs, assessing therapeutic index, identifying surrogate markers tumor progression, and defining epigenetic environmental influences on tumorigenesis.
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