Visceral fat and insulin resistance--causative or correlative?

摘要: The association between abdominal fat accumulation and risk of chronic diseases, including type II diabetes coronary heart disease, has long been recognized. Insulin resistance may be a key factor in this link. Many studies have pointed to an insulin intra-abdominal (visceral obesity). However there is no clear proof causal link visceral resistance. In assessing the probability link, it useful consider potential mechanisms. One such release non-esterified fatty acids from into portal vein, so that they direct effects on hepatic metabolism. Visceral shown many exhibit high rate lipolysis compared with subcutaneous depots. However, if idea releases vein at examined critically, number difficulties appear. Not least these fact continued rates should lead disappearance depot, unless mobilization are matched by deposition. There far less evidence for deposition adipose tissue, some contrary evidence. Evidence vivo involving catheterization not strong. If discounted, then other reasons relationship must considered. but both co-correlate variable. A possibility variable fat, which usually outweighs several-fold. Subcutaneous probably plays major role determining systemic plasma acid concentrations, relevant conclusion, present resistance, or associated metabolic syndrome. co-correlation factor, as accumulation, forgotten.