Effect of Charge Regulation and Ion-Dipole Interactions on the Selectivity of Protein-Nanoparticle Binding
作者： Fernando Luís Barroso da Silva , Mathias Boström , Clas Persson
DOI: 10.1021/LA500027F
关键词:
摘要: We investigate the role of different mesoscopic interactions (Coulomb, charge regulation, and ion-dipole “surface patch” effects) on binding bovine serum albumin (BSA) β-lactoglobulin (BLG) to a cationic gold nanoparticle (TTMA+). The results demonstrate that charge-regulation mechanism plays vital for selectivity protein–nanoparticle complexation at low salt concentration. At slightly higher ionic strengths, charge-dipole effects are dominating driving force. Thus, very small variations in concentration strongly influence origin complexation.
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