Simultaneous Comparison of Efficacy and Tolerability of Second-Generation Antipsychotics in Schizophrenia: Mixed-Treatment Comparison Analysis Based on Head-to-Head Trial Data.

摘要: ObjectiveaaSecond-generation antipsychotics have been repeatedly shown to be superior placebo. However, the comparative effi cacy among these drugs has not systematically evaluated. In this study, we used Mixed Treatment Comparison (MTC) procedures elucidate efficacy and tolerability of second-generation antipsychotics. MethodsaaSeven were selected based on availability relevant data. Data gathered from a series review article published by Cochrane Collaboration. Six outcome measures analyzed: 1) percentage no clinically important response as defined original authors, 2) PANSS total score change baseline endpoint, 3) akathisia, 4) per centage antiparkinson medication use, 5) body weight increase more than 7%, 6) drop-out due any reasons. ResultsaaAll included in study showed fairly similar but widely different tolerability. terms efficacy, amisulpride, clozapine olanzapine ranked higher aripiprazole, quetiapine ziprasidone. Clozapine akathisia extrapyramidal symptom risk, but, far prone induce gain. ConclusionaaUsing MTC methodology, could line up second generation according their hierarchical superiority Though wide overlap confidence intervals inconsistency between direct indirect comparison results may limit validity results, it still allow insights into relative merits available drugs.