High impact technologies for natural products screening.

作者: Frank E. Koehn

DOI: 10.1007/978-3-7643-8117-2_5

关键词:

摘要: Natural products have historically been a rich source of lead molecules in drug discovery. However, natural de-emphasized as high throughput screening resources the recent past, part because difficulties obtaining quality libraries, or applying modern assays to these libraries. In addition, programs based on extract bioassay-guided isolation, structure elucidation and subsequent production scale-up are challenged meet rapid cycle times that characteristic HTS approach. Fortunately, new technologies mass spectrometry, NMR other spectroscopic techniques can greatly facilitate first components process — namely efficient creation high-quality bimolecular target cell-based screening, early hit characterization.

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