Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics.
作者： Johan M. Kros , Ernst J. Delwel , Rob T. de Jong , Herve L. Tanghe , Peter R. van Run
DOI: 10.1007/S00401-002-0534-8
关键词:
摘要: In the present study clinical data, histology, proliferation rate, DNA ploidy status and results of TP53 mutation analysis comparative genomic hybridization (CGH) three typical cases desmoplastic infantile astrocytoma ganglioglioma are presented. Postoperative disease-free intervals 11, 8 3 years were recorded in none radiological signs tumor recurrence. No mutations (exons 5–8) found. CGH revealed loss 8p22-pter one case, while another case gain 13q21 was detected. with follow-up 11 an aneuploid DNA-flow cytogram along slightly increased MIB-1 labeling index (LI) The demonstrate little genetic instability these low-grade lesions. DNA-aneuploidy seems not to be indicative progression. It is concluded that aberrations found differ from those encountered common astrocytomas.
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