Periodontal disease preceding osteonecrosis of the jaw (ONJ) in cancer patients receiving antiresorptives alone or combined with targeted therapies: report of 5 cases and literature review.

摘要: Objective We present clinical and radiologic data of periodontal tissue involvement preceding the appearance osteonecrosis jaw (ONJ) in 5 patients with solid tumors, who received antiresorptives alone or combination targeted therapies. Study Design Five before dental extraction were studied. Results Periodontal was evidenced by pain, bleeding, fistula, purulence, swelling, pocket, tooth mobility. Combined endoperiodontal lesions considered 1 patient. Duration symptoms ONJ diagnosis lasted 8 to 24 weeks. Routine therapy performed 2 patients. Widening ligament observed 4 patients, dense alveolar bone seen Local complications required extractions Spontaneous exfoliation Alveolar biopsies, after confirmed osteonecrosis. Osteonecrosis healed patients—1 3 surgical debridement. Postextraction socket patient, area exposed remained asymptomatic. progressed Conclusions Clinical signs involvement, treated therapy, may represent developing