The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium
作者： Silke Frey , Anja Derer , Maria-Elena Messbacher , Dominique LP Baeten , Serena Bugatti
DOI: 10.1136/ANNRHEUMDIS-2012-202264
关键词:
摘要: Background Interleukin (IL)-36α is a recently described member of the IL-1 cytokine family with pro-inflammatory and clearly pathogenic properties in psoriasis. Objective To determine IL-36α expression psoriatic arthritis (PsA) compared to rheumatoid (RA) osteoarthritis (OA). Methods Synovial tissues obtained from patients were stained for IL-36α, IL-36 receptor (IL-36R) IL-36R antagonist (IL-36Ra) by immunohistochemistry immunofluorescence. Lysates examined western blot analysis. fibroblasts (FLS) cultured presence assayed quantitative real time PCR multiplex assay. IL-36α-induced signal transduction FLS was analysed immunoblotting. Results Expression its ligands IL-36Ra detected synovial lining layer cellular infiltrates inflammatory arthritis. expressed significantly higher PsA RA than OA synovium. CD138-positive plasma cells identified as main source IL-36α. No differences observed between PsA, OA. Functionally, induced IL-6 IL-8 through p38/NFkB activation. Conclusions up-regulated synovium, tissue leads production fibroblasts. Hence, links may represent key link autoimmunity induction synovitis.
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