Association of changes in lipids with risk of myocardial infarction among people without lipid-lowering therapy.

摘要: Abstract Background and aims Although serum lipids are widely accepted as independent predictors of myocardial infarction (MI), there is insufficient evidence for associations changes in lipid levels with MI. The present study aimed at investigating the between incidence MI people without lipid-lowering therapy. Methods 64,031 Chinese participants (mean age: 53.42 ± 11.95 years) previous were enrolled study. divided into four categories based on quartiles changes. Multivariable Cox regression models used to calculate hazard ratios (HRs) 95% confidence intervals (CIs) Results During a median follow-up 7.03 years, 599 individuals developed After adjustment covariates, increased total cholesterol (TC), low-density lipoprotein (LDL-C), non-high-density (non-HDL-C), decreased high-density (HDL-C) associated elevated risk MI, HRs (95% CIs) highest quartile group compared lowest 1.56 (1.21–2.01), 1.96 (1.49–2.57), 1.95 (1.52–2.50), 0.69 (0.53–0.90), respectively. However, triglyceride (TG) not (p = 0.8030). Conclusions Changes TC, LDL-C, non-HDL-C, HDL-C, but TG, Early detection control may be beneficial necessary young those healthy baseline.