Of mice and sigma: Conferred antibiotic resistance in the Salmonella enterica serovar Typhimurium murine model

摘要: OF MICE AND SIGMA: CONFERRED ANTIBIOTIC RESISTANCE IN THE SALMONELLA ENTERICA SEROVAR TYPHIMURIUM MURINE MODEL Rena Margaret Wallen April 6, 2012 Salmonella enterica serovar Typhimurium is an enteric pathogen capable of infecting a wide range hosts. The manner in which this able to interact with its host difficult define, as the case most microbes. Through use alternate sigma factors and other regulatory processes, S. invade cells establish systemic infections, survive assaults immune system. While strains are typically ampicillin sensitive, within host, survival inside may provide escape from many antibiotics. Previous research demonstrated that co-culture resistant Escherichia coli protection for sensitive Typhimurium. current study was attempt model relationship host. grow murine hosts presence ampicillin, it unclear whether resistance coinfection strain E. or ability avoid destruction by antibiotics invading cells.