Synthesis of the four enantiomers of diethyl 1,2-di(N-Boc-amino)propylphosphonates
作者： Iwona E. Głowacka , Dorota G. Piotrowska , Andrzej E. Wróblewski , Aleksandra Trocha
DOI: 10.1016/J.TETASY.2017.09.003
关键词:
摘要: Abstract A simple and efficient synthetic strategy to all four enantiomerically pure diethyl 1,2-di(N-Boc-amino)propylphosphonates has been elaborated starting from the corresponding N-[(R)-(1-phenylethyl)]aziridine-(2S)- N-[(S)-(1-phenylethyl)]aziridine-(2R)-carboxaldehydes, employing a one-pot three-components Kabachnik-Fields reaction followed by hydrogenolytic removal of chiral auxiliary aziridine ring opening with simultaneous protection amino groups as N-Boc derivatives.
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