Growth inhibition of nasopharyngeal carcinoma cells by EGF receptor tyrosine kinase inhibitors.

摘要: Nasopharyngeal carcinoma (NPC) is a malignancy of epithelial origin occurring with high incidence in southern China and southeast Asia. Radiotherapy the main treatment modality for NPC. No effective chemotherapy available. Since prevention EGF/EGFR binding by an EGFR specific monoclonal antibody suppressed growth NPC xenografts, we examined potential anti-NPC activity group inhibitors family tyrosine kinases. We found that HONE-T1 cells expressed levels kinase upon stimulation EGF. The receptor was specifically inhibited either reversible (PD158780) or irreversible (PD168393) This inhibition led to dose-dependent suppression anchorage-independent as determined soft agar assays. A structural analog (PD159805) no inhibitory against had effect on cell agar. Furthermore, xenografts SCID mice also PD158780 PD 168393. data provides appealing application nasopharyngeal carcinomas.