Lesions affecting the right hippocampal formation differentially impair short-term memory of spatial and nonspatial associations.

摘要: Converging evidence from behavioral and imaging studies suggests that within the human medial temporal lobe (MTL) hippocampal formation may be particularly involved in recognition memory of associative information. However, it is unclear whether processes all types associations or there a specialization for processing involving spatial Here, we investigated this issue six patients with postsurgical lesions right MTL affecting ten healthy controls. Subjects performed battery delayed match-to-sample tasks two delays (900/5,000 ms) three set sizes. were requested to remember either single features (colors, locations, shapes, letters) feature (color-location, color-shape, color-letter). In single-feature conditions, performance did not differ association significant delay-dependent deficit color-location was found. This largely independent size. By contrast, color-shape color-letter conditions normal. These findings support hypothesis region MTL, presumably formation, does equally kinds visual but rather has bias Recruitment during appears depend both on type (associative/nonassociative) to-be-remembered material (spatial/nonspatial). © 2010 Wiley-Liss, Inc.