Profound Differences in Virus Population Genetics Correspond to Protection from CD4 Decline Resulting from Feline Lentivirus Coinfection

摘要: CD4 decline is a hallmark of disease onset in individuals infected with Feline Immunodeficiency Virus (FIV) or Human type 1 (HIV-1). Cats that are poorly replicating, apathogenic FIV (PLV) prior to exposure virulent strain (FIVC) maintain numbers by mechanisms not correlated measurable adaptive immune response reduction circulating viral load. We employed population genetic approaches based on the 3' portion genome estimate structure FIVC from single and dual cats. In cats, effective size was decreased during initial expansion phase, after three weeks infection, declined sharply. The recovered pre-bottleneck levels approximately seven post-FIVC infection. However, emerging bottleneck cats distinct estimates temporal substitution profiles.