Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases.

摘要: The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all which exhibit catalytic domain common metzincin-like topology, and are involved in degradation the extracellular but also number other biologic processes. Normally, proteolytic activity MMPs is precisely regulated by their main endogenous protein inhibitors, particular tissue inhibitors (TIMPs). Disruption this balance results serious diseases such as arthritis, tumor growth, metastasis, rendering attractive targets for inhibition therapy. Knowledge tertiary structures crucial full understanding functional properties associations with dysfunctions. Since reports first atomic TIMPs 1994, considerable structural information has become available about both these families substances. Many MMP have been determined complexes synthetic facilitating knowledge-based drug design. This review focuses on currently 3D TIMPs.