Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

摘要: CD4(+)CD25(+) T cells have been proposed as the principal regulators of both self-tolerance and transplantation tolerance. Although do a suppressive role in tolerance, so CD4(+)CD25(-) cells, although 10-fold less potent. Abs to CTLA-4, CD25, IL-10, IL-4 were unable abrogate suppression mediated by tolerant spleen excluding any these molecules critical agents suppression. from naive mice can also prevent rejection despite lack previous experience donor alloantigens. However, this requires many more than tolerized provide same degree This suggests that capacity regulate transplant pre-exists mice, may be amplified "tolerized" mice. Serial analysis gene expression confirmed sorted into populations distinct they responded TCR ligation with very different programs expression. Further characterization differentially expressed genes lead development diagnostic tests monitor state.