Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials
作者： François-Clément Bidard , Tanja Fehm , Michail Ignatiadis , Jeffrey B. Smerage , Catherine Alix-Panabières
DOI: 10.1007/S10555-012-9398-0
关键词:
摘要: In 2004, circulating tumor cells (CTC) enumeration by the CellSearch® technique at baseline and during treatment was reported to be associated with prognosis in metastatic breast cancer patients. 2008, first evidence of impact CTC detection this on survival cM0(i+) patients were reported. These findings confirmed other non-interventional studies, whereas also investigated as a surrogate for biology, mainly HER2 expression/amplification. The aim report is present current prospective large interventional studies that have been specifically designed demonstrate enumeration/characterization may improve management patients: STIC METABREAST (France) Endocrine Therapy Index (USA) assess CTC-guided hormone therapy vs chemotherapy decision M1 patients; SWOG0500 CirCe01 count changes DETECT III (M1 patients, Germany) Treat (cM0(i+) European Organization Research Treatment Cancer/Breast International Group) use anti-HER2 treatments HER2-negative selected basis detection/characterization. trials different designs various patient populations but are expected pivotal implementation routine
springer.com
ulb.ac.be
core.ac.uk
paperity.org
researchgate.net 参考文章(30)
Marie-Christine Etienne-Grimaldi, Patricia Formento, Armelle Degeorges, Jean-Yves Pierga, Rémi Delva, Xavier Pivot, Florence Dalenc, Marc Espié, Corinne Veyret, Jean-Louis Formento, Mireille Francoual, Magali Piutti, Patricia de Crémoux, Gérard Milano, Prospective analysis of the impact of VEGF-A gene polymorphisms on the pharmacodynamics of bevacizumab-based therapy in metastatic breast cancer patients British Journal of Clinical Pharmacology. ,vol. 71, pp. 921- 928 ,(2011) , 10.1111/J.1365-2125.2010.03896.X
François-Clément Bidard, David Hajage, Thomas Bachelot, Suzette Delaloge, Etienne Brain, Mario Campone, Paul Cottu, Philippe Beuzeboc, Emilie Rolland, Claire Mathiot, Jean-Yves Pierga, Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: a prospective observational study. Breast Cancer Research. ,vol. 14, pp. 1- 10 ,(2012) , 10.1186/BCR3114
Michail Ignatiadis, Christine Desmedt, Christos Sotiriou, Evandro de Azambuja, Martine Piccart, HER-2 as a target for breast cancer therapy. Clinical Cancer Research. ,vol. 15, pp. 1848- 1852 ,(2009) , 10.1158/1078-0432.CCR-08-1844
F.-C. Bidard, C. Mathiot, S. Delaloge, E. Brain, S. Giachetti, P. de Cremoux, M. Marty, J.-Y. Pierga, Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer Annals of Oncology. ,vol. 21, pp. 729- 733 ,(2010) , 10.1093/ANNONC/MDP391
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) European Journal of Cancer. ,vol. 45, pp. 228- 247 ,(2009) , 10.1016/J.EJCA.2008.10.026
Antonio Giordano, Mario Giuliano, Michelino De Laurentiis, Antonio Eleuteri, Francesco Iorio, Roberto Tagliaferri, Gabriel N Hortobagyi, Lajos Pusztai, Sabino De Placido, Kenneth Hess, Massimo Cristofanilli, James M Reuben, None, Artificial neural network analysis of circulating tumor cells in metastatic breast cancer patients Breast Cancer Research and Treatment. ,vol. 129, pp. 451- 458 ,(2011) , 10.1007/S10549-011-1645-5
B Rack, C Schindlbeck, U Andergassen, R Lorenz, T Zwingers, A Schneeweiss, W Lichtenegger, MW Beckmann, H Sommer, K Pantel, K Friese, W Janni, Abstract S6-5: Prognostic Relevance of Circulating Tumor Cells in the Peripheral Blood of Primary Breast Cancer Patients Cancer Research. ,vol. 70, ,(2010) , 10.1158/0008-5472.SABCS10-S6-5
Brigitte Rack, Julia Jückstock, Maria Günthner-Biller, Ulrich Andergassen, Julia Neugebauer, Philip Hepp, Alexandra Schoberth, Doris Mayr, Thomas Zwingers, Christian Schindlbeck, Klaus Friese, Wolfgang Janni, Trastuzumab clears HER2/neu-positive isolated tumor cells from bone marrow in primary breast cancer patients. Archives of Gynecology and Obstetrics. ,vol. 285, pp. 485- 492 ,(2012) , 10.1007/S00404-011-1954-2
Michail Ignatiadis, Françoise Rothé, Carole Chaboteaux, Virginie Durbecq, Ghizlane Rouas, Carmen Criscitiello, Jessica Metallo, Naima Kheddoumi, Sandeep K. Singhal, Stefan Michiels, Isabelle Veys, José Rossari, Denis Larsimont, Birgit Carly, Marta Pestrin, Silvia Bessi, Frédéric Buxant, Fabienne Liebens, Martine Piccart, Christos Sotiriou, HER2-Positive Circulating Tumor Cells in Breast Cancer PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0015624
Tanja Fehm, Volkmar Müller, Bahriye Aktas, Wolfgang Janni, Andreas Schneeweiss, Elmar Stickeler, Claus Lattrich, Christian R. Löhberg, Erich Solomayer, Brigitte Rack, Sabine Riethdorf, Christoph Klein, Christian Schindlbeck, Kerstin Brocker, Sabine Kasimir-Bauer, Diethelm Wallwiener, Klaus Pantel, HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Research and Treatment. ,vol. 124, pp. 403- 412 ,(2010) , 10.1007/S10549-010-1163-X