Effects of etomidate on vasopressor use in patients with sepsis or severe sepsis: A propensity-matched analysis
作者： Nerissa J. Alday , G. Morgan Jones , Lauren A. Kimmons , Gary S. Phillips , Jennifer W. McCallister
DOI: 10.1016/J.JCRC.2014.02.002
关键词:
摘要: Abstract Purpose The safety of single-bolus etomidate to facilitate intubation in septic patients is controversial due its potential suppress adrenal steroidogenesis. purpose this study was evaluate the effects on development shock when used as an induction agent patients. Methods A multicenter, retrospective, propensity-matched cohort comparing with sepsis or severe who either received did not receive for conducted. primary outcome difference need vasopressor support within 72 hours after intubation. Secondary outcomes included use multiple vasopressors, intensive care unit length stay, and in-hospital mortality. Results total 411 were analyzed. Eighty-three matched by propensity score. There no regards (odds ratio, 0.95; 95% confidence interval, 0.52-1.76; P = .88). Furthermore, there significant differences observed regard secondary outcomes, including mortality (P .76). Conclusions increase requirements
sci-hub.se 参考文章(25)
Barbara Sianesi, Edwin Leuven, PSMATCH2: Stata module to perform full Mahalanobis and propensity score matching, common support graphing, and covariate imbalance testing Statistical Software Components. ,(2003)
William L Jackson, Should We Use Etomidate as an Induction Agent for Endotracheal Intubation in Patients With Septic Shock?: A Critical Appraisal Chest. ,vol. 127, pp. 1031- 1038 ,(2005) , 10.1378/CHEST.127.3.1031
David F. Gaieski, Mark E. Mikkelsen, Roger A. Band, Jesse M. Pines, Richard Massone, Frances F. Furia, Frances S. Shofer, Munish Goyal, Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department* Critical Care Medicine. ,vol. 38, pp. 1045- 1053 ,(2010) , 10.1097/CCM.0B013E3181CC4824
Chee Man Chan, Anthony L. Mitchell, Andrew F. Shorr, Etomidate is associated with mortality and adrenal insufficiency in sepsis: A meta-analysis* Critical Care Medicine. ,vol. 40, pp. 2945- 2953 ,(2012) , 10.1097/CCM.0B013E31825FEC26
Diane Lipiner-Friedman, Charles L Sprung, Pierre François Laterre, Yoram Weiss, Sergey V Goodman, Michael Vogeser, Josef Briegel, Didier Keh, Mervyn Singer, Rui Moreno, Eric Bellissant, Djillali Annane, Corticus Study Group, None, Adrenal function in sepsis: The retrospective Corticus cohort study Critical Care Medicine. ,vol. 35, pp. 1012- 1018 ,(2007) , 10.1097/01.CCM.0000259465.92018.6E
Roxanna Bloomfield, David Noble, Etomidate and intensive care physicians Intensive Care Medicine. ,vol. 31, pp. 1453- 1453 ,(2005) , 10.1007/S00134-005-2754-6
Brian H. Cuthbertson, Charles L. Sprung, Djillali Annane, Sylvie Chevret, Mark Garfield, Serge Goodman, Pierre-Francois Laterre, Jean Louis Vincent, Klaus Freivogel, Konrad Reinhart, Mervyn Singer, Didier Payen, Yoram G. Weiss, The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock Intensive Care Medicine. ,vol. 35, pp. 1868- 1876 ,(2009) , 10.1007/S00134-009-1603-4
E. Diaz-Guzman, E. Mireles-Cabodevila, G. A. Heresi, S. R. Bauer, A. C. Arroliga, A Comparison of Methohexital Versus Etomidate for Endotracheal Intubation of Critically Ill Patients American Journal of Critical Care. ,vol. 19, pp. 48- 54 ,(2010) , 10.4037/AJCC2010562
Stuart A. Forman, David S. Warner, Clinical and molecular pharmacology of etomidate. Anesthesiology. ,vol. 114, pp. 695- 707 ,(2011) , 10.1097/ALN.0B013E3181FF72B5
Charles L. Sprung, Djillali Annane, Didier Keh, Rui Moreno, Mervyn Singer, Klaus Freivogel, Yoram G. Weiss, Julie Benbenishty, Armin Kalenka, Helmuth Forst, Pierre-Francois Laterre, Konrad Reinhart, Brian H. Cuthbertson, Didier Payen, Josef Briegel, Hydrocortisone Therapy for Patients with Septic Shock The New England Journal of Medicine. ,vol. 358, pp. 111- 124 ,(2008) , 10.1056/NEJMOA071366