Differential Effects of Chronic Oral Antihypertensive Therapies on Systemic Arterial Circulation and Ventricular Energetics in African-American Patients

摘要: Background A comprehensive evaluation of arterial load characteristics and left ventricular energetics in systemic hypertension has been limited by the need for invasive techniques to access instantaneous aortic pressure flow. As a consequence this methodological limitation, no data exist on effects long-term antihypertensive therapy global impedance properties indexes myocardial oxygen consumption (MVo2). Using recently validated noninvasive techniques, we compared hypertensive patients chronic oral treatment with ramipril, nifedipine, atenolol mechanical power dissipation as well MVo2. Methods Results Sixteen African-American subjects were studied randomized, double-blind, crossover protocol. Instantaneous central flow, from which can be derived, estimated calibrated subclavian pulse tracings (SPTs) continuo...