Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies.

摘要: Dietary intake of fatty acids may be related to dementia and cognitive function through a number plausible mechanisms, such as atherosclerosis thrombosis, inflammation, via an effect on brain development membrane functioning, or accumulation beta-amyloid. This review gives overview the few studies that have investigated relationship between acid (including from fish) summarises results two Dutch population-based prospective studies: Zutphen Elderly Study (n=476) Rotterdam (n=5,386). Additionally, limitations dietary are discussed possible mechanisms behind associations. Data showed high intakes following nutrients were associated with increased risk after adjustment for confounders: total fat (RR=2.4 (95%CI: 1.1-5.2)), saturated (RR=1.9 0.9-4.0)), cholesterol (RR=1.7 0.9-3.2)). A fish consumption, important source n-3 PUFAs, reduced (RR=0.4 0.2-0.9)). In linoleic was impairment (OR=1.8 1.0-3.0)). consumption tended inversely decline (RR=0.5, 95%CI: 0.2-1.2). Since diet is factor suitable intervention these hopeful potentially very important.