Aging in Sensory and Motor Neurons Results in Learning Failure in Aplysia californica
作者： Andrew T. Kempsell , Lynne A. Fieber
DOI: 10.1371/JOURNAL.PONE.0127056
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摘要: The physiological and molecular mechanisms of age-related memory loss are complicated by the complexity vertebrate nervous systems. This study takes advantage a simple neural model to investigate system aging, focusing on changes in learning form behavioral sensitization vivo synaptic facilitation vitro. effect aging tail withdrawal reflex (TWR) was studied Aplysia californica at maturity late annual lifecycle. We found that short-term TWR absent aged Aplysia. implied neuronal machinery governing nonassociative compromised during aging. Synaptic plasticity between sensory motor neurons decreased whether sensitizing stimulus shock or heterosynaptic modulator serotonin (5-HT). Together, these results suggest cellular thereby nearly eliminating
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