Eradication of Helicobacter pylori infection decreases risk for dyslipidemia: A cohort study.

摘要: Background Previous studies have suggested a relationship between Helicobacter pylori infection and dyslipidemia; however, large-scale longitudinal not elucidated this association. This study assessed the effects of H. eradication on lipid profiles in large cohort. Methods cohort included 2,626 adults without dyslipidemia at baseline, who participated repeated, regular health-screening examination, which upper gastrointestinal endoscopy, January 2009 December 2018. The primary outcome was incident follow-up. Results During 10,324 person-years follow-up, participants with persistent had higher incidence rate (130.5 per 1,000 person-years) than those whose infections been successfully controlled (98.1 person-years). In multivariable model adjusted for age, sex, waist circumference, smoking status, alcohol intake, education level, group associated lower risk (HR, 0.85; 95% CI, 0.77-0.95; p = 0.004). association persisted after further adjustment baseline levels low-density high-density lipoprotein cholesterol 0.87; 0.79-0.97; 0.014). Conclusions may play pathophysiologic role development dyslipidemia, whereas might decrease dyslipidemia.