Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D.

摘要: Background/aims: Liver biopsy to assess fibrosis is invasive and prone sampling error. While algorithms of serum markers predict fib- rosis stage have been described for chronic hepatitis C, these cannot be applied equally well B. Methods: We therefore determined 9 markers, liver biochemical tests ultrasound parameters in 109 consecutive adult patients with B D. All had compensated disease. Using the METAVIR score, advanced disease was defined as ≥F2, active inflam- mation grade ≥A2. A gold standard created considering splenomegaly and/or platelets <150,000 indicators ir- respective histology. Area under receiver operating characteristics curves used assessment single odds ratio their combinations. Results: Patients were older, lower albumin, higher gamma glutamyl transferase plate- let. Levels 6 tissue inhibitor metalloproteinases-1, procollagen type III aminoterminal propeptide, matrix metal- loproteinase-2, laminin, hyaluronan collagen IV correlated fibrosis. Markers useful prediction also predicted marked inflammation. standard, age, prothrombin time, albumin independent predic- tors ratio's 3.11, 4.18, 3.35 5.25, respectively. Their combined use an 228.8. Tis- sue metalloproteinases-1 powerful predictors (Odds 8.65 8.38). revealed 28.6, when compared standard. Conclusion: In conclusion, hepati- tis D may two markers.