Conformational analysis of methionine-enkephalin and some analogs.
作者： Frank A. Momany
DOI: 10.1016/0006-291X(77)91495-4
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摘要: Abstract Conformational energy calculations on Methionine-Enkephalin and several of its analogues indicate that the calculated lowest conformation native enkephalin may not be conformer which interacts at opioid active site. Substitution end groups various D L-Alanine analogs were examined a low differs from was found for very analog, [D-Ala2]-Met-Enkephalin-NH2. The stereopositions side-chain functional are discussed compared to structure morphine.
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sci-hub.se 参考文章(8)
C. Pert, A Pert, J. Chang, B. Fong, (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic Science. ,vol. 194, pp. 330- 332 ,(1976) , 10.1126/SCIENCE.968485
F. A. Momany, Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. I. Native decapeptide. Journal of the American Chemical Society. ,vol. 98, pp. 2990- 2996 ,(1976) , 10.1021/JA00426A052
L. Terenius, A. Wahlström, G. Lindeberg, S. Karlsson, U. Ragnarsson, Opiate receptor affinity of peptides related to Leu-enkephalin Biochemical and Biophysical Research Communications. ,vol. 71, pp. 175- 179 ,(1976) , 10.1016/0006-291X(76)90265-5
F. A. Momany, L. M. Carruthers, R. F. McGuire, H. A. Scheraga, Intermolecular potentials from crystal data. III. Determination of empirical potentials and application to the packing configurations and lattice energies in crystals of hydrocarbons, carboxylic acids, amines, and amides The Journal of Physical Chemistry. ,vol. 78, pp. 1595- 1620 ,(1974) , 10.1021/J100609A005
F. A. Momany, Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 2. Tetrapeptide and decapeptide analogues. Journal of the American Chemical Society. ,vol. 98, pp. 2996- 3000 ,(1976) , 10.1021/JA00426A053
F. A. Momany, L. M. Carruthers, H. A. Scheraga, Intermolecular potentials from crystal data. IV. Application of empirical potentials to the packing configurations and lattice energies in crystals of amino acids The Journal of Physical Chemistry. ,vol. 78, pp. 1621- 1630 ,(1974) , 10.1021/J100609A006
F. A. Momany, R. F. McGuire, A. W. Burgess, Harold A. Scheraga, Energy parameters in polypeptides. VII. Geometric parameters, partial atomic charges, nonbonded interactions, hydrogen bond interactions, and intrinsic torsional potentials for the naturally occurring amino acids The Journal of Physical Chemistry. ,vol. 79, pp. 2361- 2381 ,(1975) , 10.1021/J100589A006
D.H. Coy, A.J. Kastin, A.V. Schally, O. Morin, N.G. Caron, F. Labrie, J.M. Walker, R. Fertel, G.G. Berntson, C.A. Sandman, Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin Biochemical and Biophysical Research Communications. ,vol. 73, pp. 632- 638 ,(1976) , 10.1016/0006-291X(76)90857-3