Neural correlates of telling lies

摘要: Rationale and objective Intentional deception (ie, lying) is a complex cognitive act, with important legal, moral, political, economic implications. Prior studies have identified activation of discrete anterior frontal regions, such as the ventrolateral prefrontal cortex (VLPFC), dorsolateral (DLPFC), dorsal medial (DMPFC), cingulate (ACC) during deception. To extend these findings, we used novel real-time functional magnetic resonance imaging (fMRI) technology to simulate polygraph experience in order evoke performance anxiety about generating lies, sought ascertain neural correlates Materials methods In this investigational fMRI study done 4-T scanner, examined lying 14 healthy adult volunteers while they performed modified card version Guilty Knowledge Test (GKT), understanding that their brain activity was being monitored real time by investigators conducting study. The were instructed attempt generate Lies would not changes activity, told responses closely monitored. Results Subjects reported task. Deceptive specifically associated VLPFC, DLPFC, DMPFC, superior temporal sulcus. Discussion These findings suggest involvement regions lying, substrates responsible for control behavior may also be engaged