Investigating biological activity spectrum for novel quinoline analogues

摘要: The lack of the wide spectrum biological data is an important obstacle preventing efficient molecular design. Quinoline derivatives are known to exhibit a variety effects. In current publication, we tested series novel quinoline analogues for their photosynthesis-inhibiting activity (the inhibition photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and reduction chlorophyll content Chlorella vulgaris Beij.). Moreover, antiproliferative was measured using SK-N-MC neuroepithelioma cell line. We described structure-activity relationships (SAR) between chemical structure effects synthesized compounds. also lipophilicity compounds by means RP-HPLC illustrate retention parameter logK logarithm capacity factor K) logP calculated available programs.