Pathology and Molecular Genetics of Common Brain Tumors

摘要: Publisher Summary This chapter provides an outline of the surgical pathology and recognized genetic molecular changes common tumors nervous system in children adults. The histological basis for classification malignancy grading some diagnostic problems are also addressed. Many brain morphologically heterogeneous, is dependent on recognition areas with characteristic histology a particular tumor type. However, data more often being requested addition to histopathological findings. In many other oncology, such as lymphoma, breast cancer, sarcoma diagnosis, norm. increasing number evidence indicate that mutation at codon 132 IDH1 (or rarely 172 IDH2) combined either TP53 or total 1p/19q loss frequent early change majority oligodendroglial tumors, diffuse astrocytomas, anaplastic secondary glioblastomas, but not primary glioblastomas. As new forms targeted therapy introduced found be effective, analysis specimens will have extended provide clinically relevant data; medical professionals must able both this information interpret