The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons
作者： Sharon K. Michelhaugh , Carolyn Fiskerstrand , Elizabeth Lovejoy , Michael J. Bannon , John P. Quinn
DOI: 10.1046/J.1471-4159.2001.00647.X
关键词:
摘要: The dopamine (DAT) and serotonin (SERT) transporter genes both contain variable number of tandem repeats (VNTR) in non-coding gene regions which have been correlated with a predisposition to variety CNS disorders. There is considerable homology between individual DAT SERT repeat DNA sequences, reflected their ability compete each other for specific protein binding as demonstrated by electrophoretic mobility shift assay. VNTR has recently shown act transcriptional enhancer. Because the similarities VNTRs, may also enhance transcription. This study demonstrates lipid transfection into an immortalized dopaminergic cell line biolistic neurons neonatal rat midbrain slices that human nine-repeat can enhancing activity suggests play role regulation expression.
sci-hub.se 参考文章(19)
Paola Sacchetti, Todd R. Mitchell, James G. Granneman, Michael J. Bannon, Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism. Journal of Neurochemistry. ,vol. 76, pp. 1565- 1572 ,(2001) , 10.1046/J.1471-4159.2001.00181.X
Jin H. Son, Hong S. Chun, Tong H. Joh, Sunghee Cho, Bruno Conti, Jong W. Lee, Neuroprotection and Neuronal Differentiation Studies Using Substantia Nigra Dopaminergic Cells Derived from Transgenic Mouse Embryos The Journal of Neuroscience. ,vol. 19, pp. 10- 20 ,(1999) , 10.1523/JNEUROSCI.19-01-00010.1999
S el Mestikawy, T Yang-Feng, B Giros, N Godinot, M G Caron, H Han, K Zheng, Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Molecular Pharmacology. ,vol. 42, pp. 383- 390 ,(1992)
S. Battersby, A. D. Ogilvie, C. A.D. Smith, D. H.R. Blackwood, W. J. Muir, J. P. Quinn, G. Fink, G. M. Goodwin, A. J. Harmar, Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatric Genetics. ,vol. 6, pp. 177- 182 ,(1996) , 10.1097/00041444-199624000-00001
J.P. Quinn, A.R. Farina, Autoimmune antigen Ku is enriched on oligonucleotide columns distinct from those containing the octamer binding protein DNA consensus sequence. FEBS Letters. ,vol. 286, pp. 225- 228 ,(1991) , 10.1016/0014-5793(91)80979-D
Cathy L Barr, Chun Xu, Jamie Kroft, Yu Feng, Karen Wigg, Gwyneth Zai, Rosemary Tannock, Russell Schachar, Molly Malone, Wendy Roberts, Markus M Nöthen, Frank Grünhage, David J Vandenbergh, George Uhl, Glen Sunohara, Nicole King, James L Kennedy, Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder Biological Psychiatry. ,vol. 49, pp. 333- 339 ,(2001) , 10.1016/S0006-3223(00)01053-2
G M Miller, R De La Garza, M A Novak, B K Madras, Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Molecular Psychiatry. ,vol. 6, pp. 50- 58 ,(2001) , 10.1038/SJ.MP.4000809
K. -P. Lesch, U. Balling, J. Gross, K. Strauss, B. L. Wolozin, D. L. Murphy, P. Riederer, Organization of the human serotonin transporter gene Journal of Neural Transmission. ,vol. 95, pp. 157- 162 ,(1994) , 10.1007/BF01276434
David J. Vandenbergh, Antonio M. Persico, Anita L. Hawkins, Constance A. Griffin, Xiang Li, Ethylin Wang Jabs, George R. Uhl, Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics. ,vol. 14, pp. 1104- 1106 ,(1992) , 10.1016/S0888-7543(05)80138-7
A. MacKenzie, J. Quinn, A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 15251- 15255 ,(1999) , 10.1073/PNAS.96.26.15251