Chymotrypsin C mutations in chronic pancreatitis.
作者： Jiayi Zhou , Miklós Sahin-Tóth
DOI: 10.1111/J.1440-1746.2011.06791.X
关键词:
摘要: Chronic pancreatitis is a persistent inflammatory disorder characterized by destruction of the pancreatic parenchyma, maldigestion, and chronic pain. Mutations in chymotrypsin C (CTRC) gene encoding digestive enzyme CTRC have been shown to increase risk European Asian populations. Here, we review biochemical properties physiological functions human CTRC, summarize functional defects associated with mutations, discuss mechanistic models that might explain increased disease carriers.
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