Effects of endothelin in the systemic and renal vascular beds in vivo

摘要: The effects of intravenous (i.v.) and intrarenal (i.a.) injections endothelin on systemic renal vascular resistances were investigated. I.v. bolus injection endothelin, 300 ng, decreased arterial pressure perfusion pressure. This vasodilator response to i.v. was dose-related at the 100, 1000 ng doses. I.a. 10 30 In contrast, 100 into arteries, produced a biphasic higher doses, increased Although initially reported as an endothelial-derived peptide with vasoconstrictor properties, present data suggest that physiologic effect this may be vasodilation