Endoscopic Endonasal Management of Metastatic Lesions of the Anterior Skull Base: Case Series and Literature Review

摘要: Background The anterior skull base is an uncommon site for brain metastases. A limited number of cases have been reported where a region the accessed through expanded/extended transsphenoidal route. In addition, reports overall and progression-free survival rates are lacking. Objective To report metastases treated with aggressive endoscopic endonasal surgery radiation therapy. Methods We retrospectively review prospective database patients at New York Presbyterian Hospital undergoing expanded from 2004 to 2014. From this database, we identified all whose final pathology revealed metastatic lesion in midline base. Results Seven hundred forty-nine underwent surgery. Final 12 (1.6%) metastasis sellar or parasellar region. Tumors were located sella, suprasellar cistern, clivus, ethmoid sinuses, sphenoid sinus, cavernous craniovertebral junction. Breast lung cancers most common primary diagnoses. Gross total resection was achieved 41.6% patients. There no postoperative cerebrospinal fluid leaks. Adjuvant therapy used 92% cases. Median follow-up 14 months (range, 1–55). 18 16 months, respectively. Conclusions range lesions that can be managed endonasally has increased advent extended surgical approaches. Favorable results obtained approach as part management paradigm