Lack of heterologous receptor desensitization induced by angiotensin II type 1 receptor activation in isolated normal rat thoracic aorta.
作者： Teresa Pérez , Ruth M. López , Pedro López , Carlos Castillo , Enrique F. Castillo
DOI: 10.1016/J.VPH.2010.11.002
关键词:
摘要: We tested whether heterologous receptor desensitization induced by activation of AT1 receptors may explain the purported relaxation produced angiotensin II in normal rat aorta. Also, role for AT2 promotion vasodilation was studied. In endothelium-intact and endothelium-denuded aortic rings, elicited biphasic contractions, which were significantly depressed when repeated each tissue. Angiotensin responses on phenylephrine preconstricted tissues, without reducing precontractile tone. These abolished presence antagonist losartan, but no relaxing to uncovered. PD123319 did not influence tissues precontracted with phenylephrine; thus, under blockade contractile effects overexposed. conclusion, II-induced can be attributed rapid time. Desensitization proved homologous nature, since tone (i.e., induce α1-adrenergic desensitization). found functional evidence participation contractions. does exert relaxant
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