Visceral larva migrans in French adults: a new disease syndrome?

摘要: Visceral larva migrans is apparently an endemic disease among adults in southwest France. Thirty-seven living the Midi-Pyrenees region of France were confirmed as having visceral based on increased specific antibody titer to Toxocara canis detected by enzyme-linked immunosorbent assay (ELISA) and Western blot method. The was characterized clinically weakness, pruritus, rash, difficulty breathing, abdominal pain, pathologically allergic manifestations including eosinophilia serum immunoglobulin (Ig) E levels. Conditional logistic regression analysis using a control group 37 hospital patients with other conditions who individually matched age sex revealed risk for associated hunting or household hunter (odds ratio (OR) = 9.0, p 0.02) village less than 500 persons (OR 5.7, 0.04). Owning two more dogs compared owning one no 9.6 vs. OR 4.5) nonhunting households 2.1 1.0). These findings, however, could not be duplicated when 60 age- sex-matched neighbors used second group.