Surface PEGylation of mesoporous silica materials via surface-initiated chain transfer free radical polymerization: Characterization and controlled drug release.
作者： Long Huang , Meiying Liu , Liucheng Mao , Qiang Huang , Hongye Huang
DOI: 10.1016/J.MSEC.2017.07.039
关键词:
摘要: Abstract As a new type of mesoporous silica materials with large pore diameter (pore size between 2 and 50 nm) high specific surface areas, SBA-15 has been widely explored for different applications especially in the biomedical fields. The modification functional polymers demonstrated to be an effective way improving its properties performance. In this work, we reported preparation PEGylated polymer composites through surface-initiated chain transfer free radical polymerization first time. thiol group was introduced on via co-condensation γ-mercaptopropyltrimethoxysilane (MPTS), that were utilized initiate using poly(ethylene glycol) methyl ether methacrylate (PEGMA) itaconic acid (IA) as monomers. successful poly(PEGMA- co -IA) copolymers evidenced by series characterization techniques, including 1 H NMR, FT-IR, TGA XPS. final SBA-15-SH- display well water dispersity loading capability towards cisplatin (CDDP) owing introduction hydrophilic PEGMA carboxyl groups. Furthermore, CDDP could released from SBA-15-SH-poly(PEGMA- -IA)-CDDP complexes pH dependent behavior, suggesting potential controlled drug delivery -IA). More importantly, strategy should also useful fabrication many other advantages monomer adoptability polymerization.
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