Effect of Blood Donor Characteristics on Transfusion Outcomes: A Systematic Review and Meta-Analysis

摘要: Optimal selection of blood donors is critical for ensuring the safety products. The current process concerned principally with donor at time donation and recipient transfusion. Recent evidence suggests that characteristics may affect short- long-term transfusion outcomes transfused recipient. We conducted a systematic review primary objective assessing association between red cell (RBC) outcomes. searched MEDLINE, EMBASE, Cochrane Central databases performed manual searches top journals all available prospective retrospective studies. described study characteristics, methodological quality, risk bias provided study-level effect estimates and, when appropriate, pooled 95% confidence intervals using Mantel-Haenszel or inverse variance approach. overall quality was graded Grading Recommendations Assessment, Development Evaluation (GRADE) methodology. From 6121 citations identified by our literature search, 59 studies met eligibility criteria (50 observational, 9 interventional). evaluation 17 on RBC outcome. confounding included high. as very low to characteristics. Potential associations were observed sex reduced survival 90 days 6 months in male recipients receive donated from females (hazard ratio 2.60 [1.09, 6.20] hazard 2.40 [1.10, 5.24], respectively; n = 1), Human Leukocyte Antigen - antigen D Related (HLA-DR) selected transfusions (odds [OR] 0.39 [0.15, 0.99] transplant alloimmunization, 9), presence antileukocyte antibodies (OR 5.84 [1.66, 20.59] transfusion-related acute lung injury, 4), antigens 0.20 [0.08, 0.52] 4). Based poor evidence, positive antibodies, female recipients, HLA-DR transfusion, Our findings be associated warrant establishing vein-to-vein data infrastructure allow large robust evaluations. PROSPERO registration number: CRD42013006726.