Dynamic range of frontoparietal functional modulation is associated with working memory capacity limitations in older adults.

摘要: Older adults tend to over-activate regions throughout frontoparietal cortices and exhibit a reduced range of functional modulation during WM task performance compared younger adults. While recent evidence suggests that is associated with poorer performance, it remains unclear whether indicative general capacity-limitations. In the current study, we examined observed over multiple levels difficulty (N-Back) predicts in-scanner out-of-scanner psychometric estimates capacity. Within our sample (60-77years age), age was negatively range. Individuals greater exhibited more accurate N-Back performance. addition, despite lack significant relationships between complex span significantly predicted domain-general Consistent previous cross-sectional findings, older individuals less activation at lowest level but highest difficulty. Our results are largely consistent existing theories neurocognitive aging (e.g. CRUNCH) focus attention on dynamic asa novel marker capacity-limitations in