Rosiglitazone, a PPAR-γ ligand, protects against burn-induced oxidative injury of remote organs

摘要: Abstract Severe burn induces the activation of an inflammatory cascade that contributes to development subsequent immunosuppression, increased susceptibility sepsis, as well generation reactive oxygen radicals and lipid peroxidation, leading multiple organ failure. In present study, we investigated whether rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) ligand is protective against burn-induced remote injury. Under brief ether anaesthesia, shaved dorsum rats were exposed 90 °C (burn group) or 25 °C (control water bath for 10 s. Rosiglitazone (4 mg/kg) saline was administered intraperitoneally immediately after at 12th hour burn. Rats decapitated 24 h injury tissue samples from lung, liver, kidney taken determination malondialdehyde (MDA) glutathione (GSH) levels, myeloperoxidase (MPO) activity collagen contents. Serum aspartate aminotransferase (AST), alanine (ALT) creatinine, blood urea concentrations (BUN) determined assess liver function, respectively. levels tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β) lactate dehydrogenase (LDH) also assayed. skin scald (30% total body surface area) caused significant decrease in GSH level, increases MDA MPO content tissues. Similarly, serum ALT, AST BUN LDH, IL-1β TNF-α elevated group compared control group. treatment reversed all these biochemical indices. According findings rosiglitazone possesses anti-inflammatory effect prevents damage organs protects damage.