Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy.
作者： Jing-Xiao Chen , Min Wang , Hui-Hui Tian , Jing-Hua Chen
DOI: 10.1016/J.COLSURFB.2015.06.039
关键词:
摘要: In this study, a series of polyion complexes (PICs) were prepared via electrostatic interaction between hyaluronic acid-histidine conjugate (HH) and polyethylenimine-histidine (PH). These PICs with the average size ranging from 410.5 nm to 98.5 at different weight ratios HH/PH able encapsulate doxorubicin (DOX) as model antitumor drug. The ratio 4:1 had negative surface charge good dispersity stability in solution containing serum. vitro drug release assay demonstrated that DOX rate higher acidic pH showing controllable property. HA coated could targetedly deliver B16F10 tumor cells, improved activity.
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