Human MRP3 transporter: identification of the 5′-flanking region, genomic organization and alternative splice variants
作者： Martin F. Fromm , Brenda Leake , Dan M. Roden , Grant R. Wilkinson , Richard B. Kim
DOI: 10.1016/S0005-2736(98)00233-8
关键词:
摘要: Abstract In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report molecular cloning two splice variants MRP3 from human liver. addition, genomic organization including 5′-flanking region and a major portion intron-exon identified characterized.
elsevier.com
sci-hub.se 参考文章(17)
Gary D. Kruh, Joseph R. Testa, Martin G. Belinsky, Kun Lee, Daphne W. Bell, Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Research. ,vol. 58, pp. 2741- 2747 ,(1998)
Kelavkar Uddhav, Shah Ketan, Advances in the Human Genome Project. A review. Molecular Biology Reports. ,vol. 25, pp. 27- 43 ,(1998) , 10.1023/A:1006834711989
Yuichi Kiuchi, Hiroshi Suzuki, Tomoko Hirohashi, Charles A Tyson, Yuichi Sugiyama, cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)1 FEBS Letters. ,vol. 433, pp. 149- 152 ,(1998) , 10.1016/S0014-5793(98)00899-0
Gerhart Kurz, Karin Barnouin, Inka Leier, Dietrich Keppler, Ulrike Buchholz, Gabriele Jedlitschky, Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Research. ,vol. 56, pp. 988- 994 ,(1996)
J. A. Juijn, G. L. Scheffer, M. Kool, F. Baas, M. De Haas, R. J. Scheper, M. J. T. Van Eijk, P. Borst, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Research. ,vol. 57, pp. 3537- 3547 ,(1997)
E. Wingender, A. E. Kel, O. V. Kel, H. Karas, T. Heinemeyer, P. Dietze, R. Knuppel, A. G. Romaschenko, N. A. Kolchanov, TRANSFAC, TRRD and COMPEL: towards a federated database system on transcriptional regulation Nucleic Acids Research. ,vol. 25, pp. 265- 268 ,(1997) , 10.1093/NAR/25.1.265
Caroline E. Grant, Ebba U. Kurz, Susan P.C. Cole, Roger G. Deeley, Analysis of the Intron–Exon Organization of the Human Multidrug-Resistance Protein Gene (MRP) and Alternative Splicing of Its mRNA Genomics. ,vol. 45, pp. 368- 378 ,(1997) , 10.1006/GENO.1997.4950
D.W. Loe, R.G. Deeley, S.P.C. Cole, Biology of the multidrug resistance-associated protein, MRP European Journal of Cancer. ,vol. 32, pp. 945- 957 ,(1996) , 10.1016/0959-8049(96)00046-9
Hans-Martin Kauffmann, Dieter Schrenk, Sequence Analysis and Functional Characterization of the 5′-Flanking Region of the Rat Multidrug Resistance Protein 2 (MRP2) Gene Biochemical and Biophysical Research Communications. ,vol. 245, pp. 325- 331 ,(1998) , 10.1006/BBRC.1998.8340
Jan Wijnholds, Raymond Evers, Manuel R. van Leusden, Carla A.A.M. Mol, Guido J.R. Zaman, Ulrich Mayer, Jos H. Beijnen, Martin Van Der Valk, Paul Krimpenfort, Piet Borst, Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nature Medicine. ,vol. 3, pp. 1275- 1279 ,(1997) , 10.1038/NM1197-1275