How to optimize binding of coated nanoparticles: coupling of physical interactions, molecular organization and chemical state

摘要: One of the key challenges in development nano carriers for drug delivery and imaging is design a system that selectively binds to target cells. A common strategy coat device with specific ligands bind strongly overexpressed receptors. However such devices are usually unable discriminate between receptors found on benign malignant We demonstrate, theoretically, how one can achieve enhanced binding cells by using multiple physical chemical interactions. study effective interactions polymer decorated micelle or nanoparticle three types model lipid membranes differ composition their outer leaflet. They are: i) receptors, ii) given fraction negatively charged lipids iii) both lipids. The coating contains mixtures two short polymers, neutral protection other polybase functional end-group optimize electrostatic head-groups. strength combined much larger than sum independent binding. find range distances where addition repulsive become an attraction case. changes shape interaction due coupling exists molecular organization, state, e.g., protonation. predictions provide guidelines carrier targeted give insight competing highly non-additive nature different nanoscale systems constrained environments ubiquitous synthetic biological systems.