The Effects of Ramelteon on Glucose Metabolism and Sleep Quality in Type 2 Diabetic Patients With Insomnia: A Pilot Prospective Randomized Controlled Trial

摘要: Background: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality glucose metabolism in diabetic patients insomnia. We administered ramelteon, an agonist melatonin, to type 2 investigated its effects on Methods: This multicenter, prospective, randomized, observational pilot study was performed between April 2014 2015 at three institutes Japan. Patients were prescribed ramelteon 8 mg/day for 3 months (first period). And divided random into continuation group that continued taking discontinuation discontinued additional (second The primary endpoint change glycated hemoglobin (HbA1c) level. Secondary endpoints changes global Pittsburgh questionnaire index (PSQI) score other makers. Results: enrolled 42 patients, 32 completed first period. Their mean HbA1c 6.7%, PSQI 8.1 average. level did not but improved from 7.2 by (P = 0.030). Thirty-one second group, it increased 6.7% 6.9% 0.003) group. Global each There no rebound Conclusion: Treatment Discontinuation slightly worsen quality. J Clin Med Res. 2016;8(12):878-887 doi: http://dx.doi.org/10.14740/jocmr2754w