Comparison of tolerability and efficacy of concurrent chemoradiation (CRT) for anal squamous cell carcinoma (SCC) in HIV-positive (HIV+) and -negative (HIV-) patients (pts)

摘要: 4606 Background: It is believed that the prognosis of anal SCC poor in HIV+ pts, and their appropriate treatment uncertain. We compared tolerability efficacy concurrent CRT as definitive therapy for HIV-/unknown pts HAART- era. Methods: Pts serially diagnosed treated a single institution from Apr/2000 to May/2007. Definitive consisted 45- 59.4Gy, divided 5 fractions/week, given with mitomycin-C (MMC) 15mg/m2D1 IV 5-fluoruracil (5FU) 1g/m2/d IV, continuous infusion, D1-D4 D29-D32. Baseline hematologic, hepatic renal functions were normal all same was delivered irrespective HIV-status. under antiretroviral according standard recommendations. Results: 78 included analysis, median age 56.5y (23–85y), 63 female (81%). Stage: Tis (3 pts), I (4), II (26), IIIA (15), IIIB (20), (1). Nine identified HIV+. younger (39.4 vs. 59.2 y, p<...