Oleate Promotes the Proliferation of Breast Cancer Cells via the G Protein-coupled Receptor GPR40
作者： Serge Hardy , Geneviève G. St-Onge , Érik Joly , Yves Langelier , Marc Prentki
关键词:
摘要: Evidence from epidemiological studies and animal models suggests a link between high levels of dietary fat intake risk breast cancer. In addition, obesity, in which circulating lipids are elevated, is associated with increased various cancers. Relative to this point, we previously showed that oleate stimulates the proliferation cancer cells phosphatidylinositol 3-kinase plays role process. Nonetheless, questions remain regarding precise mechanism(s) by promotes cell growth. Pharmacological inhibitors GTP-binding proteins Gi/Go, phospholipase C, Src, mitogenic-extracellular signal-regulated kinase 1/2 (MEK 1/2) decreased oleate-induced [3H]thymidine incorporation line MDA-MB-231. caused rapid transient rise cytosolic Ca2+ an increase protein B phosphorylation. Overexpressing these G protein-coupled receptor GPR40, fatty acid receptor, amplified proliferation, whereas silencing GPR40 gene using RNA interference it. T47D MCF-7 poorly responsive allowed robust proliferative action oleate. The data indicate MEK 1/2, 3-kinase/protein signaling pathways implicated signal induced effects mediated at least part via GPR40. results suggest control growth acids may provide
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