Pre-seroconversion immune status predicts the rate of CD4 T cell decline following HIV infection.

摘要: Objective: To study whether immune status prior to HIV seroconversion predicts CD4 T cell decline during infection. Design: Prospective cohort including 51 injecting drug users (IDU) who were negative at entry and seroconverted for follow-up. Methods: Cryopreserved peripheral blood mononuclear cells obtained before used measure naive (CD45RO-CD27+), memory (CD45RO+CD27+), total numbers, the fraction of dividing Ki67+CD4+ cells, receptor excision circles (TREC). The effect pre-seroconversion status, as defined by these markers, on rate infection was assessed using linear regression repeated measurements. Results: IDU with low TREC contents lost a significantly faster than those high content. higher numbers had 14 steeper in first 3 months infection, but their counts remained throughout Intermediate levels associated levels. highest drug-injecting frequencies showed slower injected less. No correlation present between markers duration or intensity use. Conclusion: Among IDU, measured content affects disease course after seroconversion. (C) 2004 Lippincott Williams Wilkins