The binding of agonists to brain muscarinic receptors.

摘要: The interaction of agonists with muscarinic receptors has been investigated by measuring the binding [3H]muscarinic to membrane preparations from rat cortex and means [3H]agonist/agonist [3H]antagonist/agonist competition experiments. data can be explained presence two major populations agonist sites which do not interconvert during experiments have same affinity constants for antagonists. ratio an vary 1 about 275. There is quantitative agreement between parameters derived action on smooth muscle, A third (minor) population "super-high" detected.