Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria

摘要: Due to a high unresponsiveness chemotherapy, biofilm formation is an important medical problem that frequently occurs during infection with many bacterial pathogens. In this study, the marine sponge-derived natural compounds 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol and 3,4,6-tribromo-2-(2',4'-dibromophenoxy)phenol were found exhibit broad antibacterial activity against medically relevant gram-positive gram-negative The not only bactericidal both replicating stationary phase-persistent planktonic cells of methicillin-resistant Staphylococcus aureus (MRSA) Pseudomonas aeruginosa; they also killed biofilm-incorporated species while affecting structural integrity. Moreover, these active carbapenemase-producing Enterobacter sp. This simultaneous different growth forms bacteria rare. Genome sequencing spontaneous resistant mutants proteome analysis suggest resistance mediated by downregulation EIIBC phosphotransferase components scrA mtlA in MRSA likely leading lower uptake molecules. their moderate cytotoxicity human cell lines, phenoxyphenols provide interesting new scaffold for development antimicrobial agents cells, persisters biofilm-incoporated ESKAPE KEY POINTS: • Brominated kill actively bacteria. Phosphotransferase systems mediate brominated phenoxyphenols. Downregulation resistance.