High Exploratory Phenotype Rats Exposed to Environmental Stressors Present Memory Deficits Accompanied by Immune-Inflammatory/Oxidative Alterations: Relevance to the Relationship Between Temperament and Mood Disorders.

摘要: Low-exploratory (LE) and high-exploratory (HE) rodents mimic the human depressive hyperthymic temperaments. Mood disorders (MD) may be developed by exposure of these temperaments to environmental stress (ES). Psychiatric symptoms severity in MD patients is related magnitude memory impairment. Thus, we aimed at studying consequences LE HE male Wistar rats, during periadolescence, a combination two ES, namely paradoxical sleep deprivation (PSD) unpredictable (US), on performance. We also evaluated prevention alterations lithium valproate hippocampal immune-inflammatory/oxidative, as ES. HE+ES- LE+ES-rats presented working (WM) declarative (DM) deficits. Valproate prevented WM Lithium DM impairment HE+ES-rats. Hippocampal glutathione (GSH) was 4-fold increased HE+ES-rats, being lithium. All groups levels GSH relation controls. Increments lipid peroxidation LE+ES- HE+ES-rats were both drugs LE+ES-rats. Nitrite (5-fold increase), which two-fold increase inducible nitric oxide synthase (iNOS) expression that showed plasma interleukin (IL)-1 IL-4. Indoleamine 2, 3-dioxygenase 1 (IDO1) LE+ES-rats, while tryptophan 2,3-dioxygenase (TDO2) only Altogether, our results suggest LE- HE-rats exposed ES present deficits, with presenting more brain inflammatory are partially mood-stabilizing drugs.