Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome

摘要: Objective: Laboratory studies demonstrated significant detrimental effects of male sex-steroids (testosterone) on immune functions following hemorrhagic shock and soft-tissue trauma. Moreover, better survival female mice subjected to severe sepsis was observed when compared animals. The aims the present study were evaluate whether or not gender differences regarding incidence mortality do exist in surgical intensive care patients elucidate influence patient age sepsis/septic shock.¶Design: Data base review prospectively collected data from patients.¶Setting: Surgical unit department surgery a university hospital.¶Patients: Prospectively 4218 (2709 male, 1509 female).¶Results: Significantly fewer referred (6.6 % vs 10.8 all patients; P < 0.05) leading significantly smaller proportion (35.8 64.2 %). No number failing organs procedure (exception vascular surgery) with without shock, indicating that studied are comparable general health prior admission SICU. Among SICU only 7.6 developed while 10.4 suffered septic (P 0.05). This difference results lower between 60 79 years. rates (men 64.9 %, women 65.5 %).¶Conclusions: Our indicate requiring as well patients. Mortality however, is affected by gender.