New Peptides Under the s(ORF)ace of the Genome

摘要: Hundreds, perhaps thousands of previously unidentified functional small peptides could exist in most genomes, but these sequences have been generally overlooked. The discovery genes encoding with important functions different organisms has ignited the interest and led to an increasing amount effort towards their identification. Here, we review advances, both computational biochemical, that are leading way putatively open reading frame (smORFs), as well studies carried out a consequence searches. evidence suggests smORFs form substantial part our encoded variety cellular functions.